Analytical Characterisation of Adenovirus-based Vaccines (ChAdOx & Ad5)
Time: 10:00 am
day: Day Two
• Product quality understanding is a critical part of vaccine manufacturing and regulation
• Use of mass spectrometry to identify key viral proteins that are involved in virus maturation and infectivity
• Analysis of two viral vector-based vaccines, Chimpanzee adenovirus (ChAdOx) and Human Adenovirus Type 5 (Ad5), both of which are used commercially and observed differences in key proteins that could
potentially be used as critical quality attributes (CQA).
• Proposal of this technique to be implemented for commercial vaccine production